We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


New quantitative technique shows microstructural brain alternations in autism spectrum disorder

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "New quantitative technique shows microstructural brain alternations in autism spectrum disorder"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:

A new study found significant changes in white matter pathways in the brains of individuals with autism spectrum disorder (ASD) using a novel technique called automated fiber quantification (AFQ).

Evidence of both increases and decreases in diffusion across white matter tracts and the relationship of these changes to patient age are reported in the journal Brain Connectivity.

See Also: Common brain changes found in children with autism, ADHD and OCD

Lauren Libero, University of California Davis M.I.N.D. Institute, Sacramento, CA, Wesley Burge, Hrishikesh Deshpande, and Rajesh Kana, University of Alabama at Birmingham, and Franco Pestilli, Indiana University, Bloomington, describe the AFQ technique in their article entitled "White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder."

AFQ gives researchers access to diffusion information along an entire tract of white matter, instead of having to rely on average measures, which may improve their ability to identify clinical differences that are linked to microstructural changes in the brain.

"Autism researchers have hypothesized that the disorder is caused by large-scale disruptions in brain connectivity," says Christopher Pawela, PhD, Co-Editor-in-Chief of Brain Connectivity and Assistant Professor, Medical College of Wisconsin.

Read Next: Study reveals subtle brain differences in men with autism

"Lauren Libero and colleagues support this hypothesis by demonstrating that subtle alterations of white matter tracts, which are the structural wiring system in the brain, are present in affected individuals. They performed this work using their newly developed magnetic resonance imaging methodology that provides increased sensitivity to white matter changes."

Note: Material may have been edited for length and content. For further information, please contact the cited source.

Mary Ann Liebert, Inc. Publishers


Libero LE et al. White Matter Diffusion of Major Fiber Tracts Implicated in Autism Spectrum Disorder.   Brain Connectivity, Published November 1 2016. doi: 10.1089/brain.2016.0442