Parasite Discovery Could Have Implications for Schizophrenia Treatment

New research into how a common parasite infection alters human behavior could assist the creation of treatments for schizophrenia and other neurological disorders.

Scientists say behaviour changes in those infected with T. gondii, which currently infects 2.5 billion people worldwide and causes the disease Toxoplasmosis, could be linked to lowered amounts of norepinephrine, a chemical released in the brain as part of the stress response. Norephinephrine also controls neuroinflammation, the activation of the brain's immune system against infection.

Norepinephrine and neuroinflammation are associated with neuropsychological disorders such as schizophrenia, Alzheimer's disease, and ADHD.

Although usually considered asymptomatic in humans, T. gondii infection can cause headache, confusion and seizures in others as well as an increased susceptibility to schizophrenia - and can be fatal to immunocompromised patients.

T. gondii can only sexually reproduce in cats. It forms cysts which are shed in the cat's faeces. It makes its way into new hosts through ingestion of anything contaminated by these cysts, such as water, soil or vegetables; through blood transfusions, from unpasteurised goat's milk; eating raw or undercooked meat, or from mother to foetus.

After a few weeks, the infection enters a dormant phase, whereupon cysts form in the brain. They can remain there for many years, possibly for life. It is during this stage that infection decreases the regulator of the brain's immune response norepinephrine.

The mechanisms by which the parasite affects brain function have been poorly understood. But research led by the University of Leeds and Université de Toulouse now suggests that the parasite's ability to reduce norepinephrine interrupts control of immune system activation, enabling an overactive immune response which may alter the host's cognitive states.

The findings - Noradrenergic Signaling and Neuroinflammation Crosstalk Regulates Toxoplasma gondii-Induced Behavioral Changes - have been published in Trends in Immunology.

Glenn McConkey, Associate Professor of Heredity, Disease, and Development at Leeds' School of Biology, who published the research, said: "Our insight connects the two opposing theories for how Toxoplasma alters host behaviour and this may apply to other infections of the nervous system. One school believes that behaviour changes are invoked by the immune response to infection and the other that changes are due to altered neurotransmitters."

"This research will contribute to the great need in understanding how brain inflammation is connected to cognition, which is essential for the future development of antipsychotic treatments."

Reference:

Laing C, Blanchard N, McConkey GA. Noradrenergic Signaling and Neuroinflammation Crosstalk Regulate Toxoplasma gondii-Induced Behavioral Changes. Trends in Immunology. 2020;0(0). doi:10.1016/j.it.2020.10.001

This article has been republished from materials provided by the University of Leeds. Note: material may have been edited for length and content. For further information, please contact the cited source.