Prostate- and Colon Cancer Targeted With Tapeworm Drug
Karl-Henning Kalland's research group has done experiments with hundreds of drugs to fight cancer. Credit: Kim E. Andreassen
Cancer researchers at the University of Bergen (UiB) in Norway have in the recent years experienced with hundreds of known drugs, to see how they influence cancer cells.
Recently they found that a substance in medicine against parasites like Giardia and Tapeworms, acts like tailored medicine against prostate- and colon cancer.
"We discovered that this specific substance is blocking the signalling pathway in the cancer cells, and make them stop growing. It is not often that researchers discover a substance that targets specific molecules as precisely as this one, " says Professor Karl-Henning Kalland at the Department of Clinical Science, at UiB. He is the leader of the research group.
The study is published in Nature Chemical Biology.
The researchers at Kalland team saw that the cells in prostate- and colon cancer contain high amounts of activated Beta-catenin. Activation of this protein makes the cells go amok and divides at high tempo. In addition, Beta-catenin makes the cancer cells more resistant and more able for survival.
In the study, the researchers discovered that it was the substance NTZ (nitazoxanide), a well known and approved anti-parasite drug, that decompose the activated Beta-catenin.
"We are the first researchers who have mapped the complex molecular mechanisms involved in this process," Kalland says.
Recycling old medicines
Experiments with well-known drugs show that a medicine may have different and unknown targets in the cells.
"The advantage of testing already approved drugs, is that we know they work in the human body and have no serious side effects, which means that a future treatment may happen quicker," Kalland explains.
Strengthen the immune system
NTZ attacks cancer celles by hindering the activated Beta-catenin. It appears that this hindering also stimulates central parts of the immune system, that attacks cancer cells.
"At the moment, we are working on how to strengthen our on going immune therapy against prostate cancer by using the mechanisms we discovered of the NTZ," Kalland says.
Kalland and his research-team is in the first phase in a clinical trial using immune therapy against prostate cancer (cryoIT).
This article has been republished from materials provided by University of Bergen (UiB). Note: material may have been edited for length and content. For further information, please contact the cited source.
Qu, Y., Olsen, J. R., Yuan, X., Cheng, P. F., Levesque, M. P., Brokstad, K. A., . . . Ke, X. (2017). Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nature Chemical Biology. doi:10.1038/nchembio.2510
Researchers have figured out precisely why one drug binds to the serotonin receptor 5-HT2BR and activates it to cause heart problems while very similar drugs do not. They've also discovered why a third drug acts like a 5-HT2BR antagonist - it blocks the receptor's activity - while the very well-known similar hallucinogenic drug LSD does not.READ MORE
Each year in the U.S., at least 23,000 people die from infections caused by antibiotic resistant bacteria. Using computer modeling, researchers are developing the means to prevent some of those deaths. One way bacteria develop resistance is by producing pumps that spit out antibiotics, before they can do any damage. The researchers teased out the details of how one antibiotic pump works.READ MORE