Sage-N Research Announces Sorcerer™ Online on the Internet
News Feb 14, 2006
Sage-N Research, Inc. has announced the launch of Sorcerer Online, a web-based service for high-throughput protein identification.
Sage-N Research is immediately offering free trial sign-ups to proteomics researchers who need more convenience and throughput in their searches, but are not ready to install the Sorcerer appliance in their laboratory.
"The Sorcerer appliance for proteomics research is known for its ease of use and its power," said David Chiang, C.E.O. and Chairman of Sage-N Research.
"Now, with Sorcerer functionality hosted on the Web, there's no setup at all, and the databases are ready to go. This is perfect for people whose analysis needs are more ad-hoc, yet still need to get significant work done."
Version 1.0 of Sorcerer Online is designed to offer searches of up to 10,000 MS-MS spectra against a variety of databases with options for mass settings and other parameters.
The user can apply variable post-translational modifications broadly, since Sorcerer is particularly effective with several selected. Reporting of results with confidence assessment is provided in alternative styles according to what researchers are familiar with.
These include the original Sequest format, the PeptideProphet™ and ProteinProphet™ tools of the Trans-Proteomic Pipeline of the Institute of Systems Biology, with a peptide summary report (similar to the output of Mascot®) to be added shortly.
The full Sorcerer Online feature set is available through registration, which also assures privacy of a user's data.
The system will also be previewed at the ABRF '06 meeting in Long Beach, CA from February 12-14, 2006. Users who try the service by registering online or by trying it at the ABRF meeting will be entered into a drawing for Apple® iPod® devices.
The Sorcerer Online service is powered by a multi-Sorcerer installation managed by Sage-N Research.
Each unit is an integrated data appliance that uses patent-pending Pattern Match Accelerator™ hardware and systems technology to provide processing throughput for protein identification that otherwise might require hundreds of compute nodes.
The Sorcerer appliance currently supports the SEQUEST® algorithm, with additional scoring modules under development.
Using EBX reagents, researchers have converted the C-terminal carboxylic acid of peptides into a carbon-carbon triple bond - an alkyne (in chemical jargon a "decarboxylative alkynylation"). The alkyne moiety is a very valuable functional group that can be used to further modify the peptides.READ MORE