S*BIO Collaborates with Tan Tock Seng Hospital for Therapeutic and Biomarker Evaluation of JAK2 Inhibitor SB1518
News Dec 19, 2008
S*BIO Pte Ltd has announced that it has signed a collaboration agreement with Tan Tock Seng Hospital (TTSH) in Singapore, to evaluate the effects of its JAK2 inhibitor, SB1518, on biological samples from patients with myeloproliferative neoplasms (MPNs).
S*BIO scientists will work closely with TTSH investigators to evaluate the potential therapeutic effects of SB1518 on diseased blood cells isolated from patients with MPN, and to validate the utility of biomarker assays with these patient samples.
The cellular response to drug treatment will be monitored in terms of general viability, specific apoptotic response, specific biomarker changes and JAK2 mutational status. A total of 50 patient samples will be collected for the study, through to the first quarter of 2009.
"S*BIO is dedicated to scientific excellence and our collaboration with TTSH will provide valuable insights into the therapeutic effects of SB1518 in treating MPN, while demonstrating our commitment and belief in our product candidate," said Dr. Jan-Anders Karlsson, CEO of S*BIO. "TTSH has an excellent team of physicians and we look forward to working with them in evaluating effective medicines that will provide long-term solutions to current palliative options for MPN patients."
The TTSH team will be led by Dr. Ong Kiat Hoe, a consultant haematologist from the Department of Laboratory Medicine. Co-investigators from the same department include Dr. Ponnudurai Kuperan, Dr. Lee Lian King, Dr. Fong Sing Zern and Dr. Chiam Yaw Yung.
SB1518 is a small molecule JAK2-selective kinase inhibitor which has high potency against both the wild type JAK2 kinase and the JAK2 kinase with the V617F mutation.
The V617F mutation is found in high frequencies in various myeloproliferative disorders such as idiopathic myelofibrosis. SB1518 might also provide an effective treatment for other hematological malignancies with mutations and re-arrangements in the JAK2 gene.
Mechanism Controlling Multiple Sclerosis Risk IdentifiedNews
Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.
Synthetic DNA Shuffling Enzyme Outpaces Natural CounterpartNews
A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitudeREAD MORE
Antarctic Worm and Machine Learning Help Identify Cerebral Palsy EarlierNews
A research team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients. The technique which makes use of machine learning, data science and even analysis of Antarctic worms, raises hopes for earlier targeted CP therapies.