Stress hormone elevation associated with working memory deficits in aging
News Jun 18, 2014
Animal study suggests that stress may accelerate age-related changes in the brain
A new study published in the June 18 issue of The Journal of Neuroscience adds to a body of evidence suggesting stress may accelerate cognitive decline later in life. The study found that aged rats with high levels of the stress hormone corticosterone showed structural changes in the brain and short-term memory deficits.
While most people will experience some cognitive decline as they get older, the extent of these changes and how rapidly they progress varies greatly from one person to the next. Scientists are interested in understanding the factors that contribute to these differences. Research suggests that how the body responds to stress may be one of the factors influencing how the brain ages. Multiple animal studies have linked high levels of the stress hormone corticosterone (similar to the human stress hormone cortisol) with age-related structural and functional decline in the hippocampus, a region that plays a key role in long-term memory.
Jason J. Radley of the University of Iowa wanted to know whether exposure to high levels of corticosterone is associated with other changes in the brain and memory deficits. In the current study, he and others measured the amount of the stress hormone in the blood of young and old rats and examined cells in the prefrontal cortex, a region of the brain involved in short-term memory. The researchers found that older animals with high levels of the stress hormone had fewer connections between prefrontal cortex cells than the older animals with lower levels of the hormone. In contrast, prefrontal cortex cells appeared similar in younger animals regardless of stress hormone levels.
“Older animals with higher levels of stress hormones in their blood have ‘older’ frontal cortexes than animals with less stress hormones,” explained Stanford University professor Robert Sapolsky, PhD, an expert on the damaging effects of long-term stress who was not involved with this study. “Thus, stress may act as a pacemaker of aging in this key brain region.”
Older rats with higher levels of stress hormone displayed a 20 percent reduction in the density of dendritic spines (the small protrusions on neurons that come into close contact with other cells to form synapses, the connections between cells) relative to age-matched rats with less stress hormone.
The researchers also compared how the young and old rats performed on a simple working memory task, where the animals had to remember which arm of a two-arm maze contained a food reward following varying periods of delay. Older animals with higher levels of corticosterone made more errors when attempting to predict the location of the reward than age-matched animals with less of the stress hormone after a brief period of delay.
“These findings are not meant to indicate that high stress hormones are the only factor in determining the decline of mental abilities during aging,” Radley cautioned. “Nonetheless, this study suggests that the effects of these stress hormones on the brain may be much more widespread than we previously thought.”
Note: Material may have been edited for length and content. For further information, please contact the cited source.
Rachel M. Anderson, Andrew K. Birnie, Norah K. Koblesky, Sara A. Romig-Martin, Jason J. Radley. Adrenocortical Status Predicts the Degree of Age-Related Deficits in Prefrontal Structural Plasticity and Working Memory. Journal of Neuroscience, Published Online June 18 2014. doi: 10.1523/JNEUROSCI.1385-14.2014
Convergence of Synaptic Signals is Mediated by a Protein Critical for Learning and MemoryNews
Researchers show that protein Kinase C is a novel information integrator, keeping tabs on the recent history of neighboring synapses while simultaneously monitoring local synaptic inputREAD MORE
Through the Eyes of the Crab: Binocular processing of object motion in the crustaceanNews
The widely spaced eyes and visually guided behaviors of the crab Neohelice granulata suggest it may compute visual parameters of moving targets by combining input from both eyes.READ MORE
Perinatal Exposure to Phthalates Results in Lower Number of Neurons and Synapses in the Medial Prefrontal CortexNews
Phthalates - chemicals used in plastics belonging to the same class as Bisphenol A (BPA) - can potentially interfere with hormones important for the developing brain.READ MORE