Study Identifies Single microRNA Biomarker for Prognosis of Mesothelioma Patients
News Feb 18, 2010
Rosetta Genomics, Ltd. has announced that the results of a joint study with the NYU Langone Medical Center were published online on February 16th, 2010, and are set to be published in the March 1st issue of the American Association for Cancer Research’s journal, Cancer Research.
The study, “Hsa-Mir-29c* is Linked to the Prognosis of Malignant Pleural Mesothelioma,” demonstrates the potential of a single microRNA to act as an independent prognostic factor for time to progression as well as survival after surgery.
In the study, 142 MPM tumors were analyzed for microRNA expression levels using Rosetta Genomics’ proprietary microRNA-based array and qRT-PCR technologies. The results clearly demonstrate that higher levels of miR-29c* in MPM predict a more favorable prognosis. Not only was the microRNA able to separate MPM patients by time to progression after surgery, but it also stratified these patients by their survival.
When examining Time to Progression (TTP) of MPM, the expression level of miR-29c* enabled the identification of two groups with significantly different median TTP: 4 months versus 14 months in the study’s training set, and 5.5 months versus 12.8 months in the study’s test set.
When examining survival rates for MPM, the expression level of miR-29c* enabled the identification of two groups as well: median survival of 8 months versus 32 months in the study’s training set, and median survival of 9.1 months versus 21.6 months in the study’s test set. This new diagnostic capability may help physicians apply more aggressive therapeutic modalities to the poor prognosis group.
Furthermore, the study found that over-expression of miR-29c* in mesothelioma cell lines resulted in significantly decreased proliferation, migration, invasion and colony formation.
Low Temperatures Turn Stem Cells into Calorie-Burning FatNews
The secret to healthy eating may not be in freezer food, but low temperatures can help turn stem cells into brown fat, a type of fat which helps burn calories. A new study could turn this knowledge into weight-loss treatments.READ MORE
"Non-Gene" Mutations May Hold Answers to Neurodevelopmental DisordersNews
Mutations in non-coding regions of the genome, which don't contain genes, but control the regulation of other genes, may hold answers to rare developmental disorders that affect the nervous system.READ MORE