We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Understanding the fascinating interaction between bone and brain

Understanding the fascinating interaction between bone and brain content piece image
Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.

Want to listen to this article for FREE?

Complete the form below to unlock access to ALL audio articles.

Read time: 1 minute

Scientific review describes key central regulators of bone metabolism and points to future directions and challenges in this promising area of research -

"The best news is that the brain has become front and centre in the regulation of bone modelling", conclude authors Professors Paul Dimitri and Cliff Rosen in their concise review of the complex role of the central nervous system in bone metabolism.

See Also: Enhancing neuronal activity promotes axon regeneration in adult CNS

The review "The Central Nevous System and Bone Metablism: An Evolving Story", published in Calcified Tissue International & Musculoskeletal Research, shows how our understanding of the control of skeletal metabolism has undergone a dynamic shift in the last two decades, primarily driven by greater understanding of energy metabolism. It also points to future directions and challenges faced by researchers as they try to better understand the complex interaction between the musculoskeletal and central nervous systems.

The authors review the latest research into the role of central regulators of bone metabolism, including leptin, neuropeptide Y (NPY), serotonin, endocannabinoids, cocaine- and amphetamine-regulated transcript (CART), adiponectin, melatonin and neuromedin U. They also discuss the role of the sympathetic and parasympathetic nervous systems in the control of skeletal metabolism, as evidence for the broader autonomic skeletal regulation. Sensory innervation of bone is also a focus, further extending our understanding of the complex neuronal regulation of bone mass.

Read Next: New discovery gives hope that nerves could be repaired after spinal cord injury

Professor Dimitri, Professor of Child Health & Director of Research & Innovation at Sheffield Children's Hospital NHS Foundation Trust, UK stated: "Whilst scientific advance in this field of bone metabolism has been rapid, progress is still required to understand how these model systems work in relation to the numerous and complex factors that influence skeletal metabolism, particularly in humans. Our rapidly evolving understanding of the physiological aspects of bone remodelling together with the development of more sophisticated technology will in time help us to reach this goal."

Note: Material may have been edited for length and content. For further information, please contact the cited source.

International Osteoporosis Foundation   press release


Dimitri P, Rosen C. The Central Nervous System and Bone Metabolism: An Evolving Story.   Calcified Tissue International, Published Online August 8 2016. doi: 10.1007/s00223-016-0179-6