Visualising Associations Between Paired `Omics' Data Sets
News Nov 27, 2012
Each omics platform is now able to generate a large amount of data. Genomics, proteomics, metabolomics, interactomics are compiled at an ever increasing pace and now form a core part of the fundamental systems biology framework. Recently, several integrative approaches have been proposed to extract meaningful information. However, these approaches lack of visualisation outputs to fully unravel the complex associations between different biological entities.
The multivariate statistical approaches 'regularized Canonical Correlation Analysis' and 'sparse Partial Least Squares regression' were recently developed to integrate two types of highly dimensional 'omics' data and to select relevant information. Using the results of these methods, we propose to revisit few graphical outputs to better understand the relationships between two 'omics'data and to better visualise the correlation structure between the different biological entities. These graphical outputs include Correlation Circle plots, Relevance Networks and Clustered Image Maps.
Such graphical outputs are undoubtedly useful to aid the interpretation of these promising integrative analysis tools and will certainly help in addressing fundamental biological questions and understanding systems as a whole.
The article is published online in the journal BioData Mining and is free to access.
Bacterial Control Mechanism for Adjusting to Changing ConditionsNews
A fundamental prerequisite for life on earth is the ability of living organisms to adapt to changing environmental conditions. Physicists have now determined that the regulation mechanisms used by bacteria to adapt to different environments are based on a global control process that can be described in a single equation.READ MORE
Cracking the Code of Coenzyme Q BiosynthesisNews
Coenzyme Q is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. Researchers are developing new tools to shed light on CoQ function, primarily by finding and defining proteins that have a direct link to the chemical. This includes the development of a new multi-omic strategy to identify the global function of an RNA-binding protein that has long been associated with mitochondria and its role in CoQ biosynthesis.READ MORE
CMC Biologics Announces Development and Manufacturing Agreement with Harpoon TherapeuticsNews
Companies have entered into agreement for the development and manufacturing of three TriTAC molecules for the treatment of cancers.READ MORE