Live-Cell Kinetic Analysis of Microglial Function and Morphology
Microglia are the resident immune cells of the central nervous system and play significant roles in the regulation of homeostasis and the management of tissue response to inflammatory or pathological insults.
Improved Expansion of Neural Stem Cells with Gibco™ Heat Stable Recombinant Human Basic Fibroblast Growth Factor
Basic fibroblast growth factor (bFGF) is used in neural stem cell (NSC) media to maintain multipotency. Native bFGF rapidly loses biological activity when exposed to culture conditions (37°C), Heat Stable (HS) bFGF maintains > 90% homology to the native protein and ≥ 80% biological activity, even after 72 hours of exposure to 37°C.
The Inhibition Pathways of Human Islet Amyloid Polypeptide
Download this poster to find out more about human islet amyloid polypeptide (hIAPP) and the inhibitors most successful at preventing hIAPP aggregation.
3D Spheroid Culture Workflow using iPSC-induced Human Neurons
To develop a neuronal 3D spheroid culture system, we tested iPSC-derived human motor neurons and cortical glutamatergic neurons using the S-BIO PrimeSurface Ultra Low Attachment Micoplates.
Spontaneous Calcium Oscillations of Networked Human iPSC Derived Cortical Neurons as a Sensitive Model for Neurotoxicity Screening
BrainXell's human neuron culture platforms provide a means to model the human brain in a dish and perform in vitro functional assays. This system enables the screening of disease phenotypes and pharmacological agents that alter neuronal activity.
Identification of New Hit Compounds Using a High-Throughput Phenotypic Screen with SMA Patient iPSC-Derived Motor Neurons
Spinal muscular atrophy (SMA) is an inheritable cause of infant mortality that is characterized by the loss of lower motor neurons and skeletal muscle atrophy. The degeneration of motor neurons is caused by insufficient levels of survival motor neuron (SMN) protein, which is encoded by two nearly identical genes SMN1 and SMN2. Most cases of SMA harbour homozygous deletions of the SMN1 gene and retain at least one copy of SMN2.
Optimized Conditions for MEA Assay with Human iPSC-Derived Spinal Motor Neurons, Glutamatergic Neurons and Mixed Cortical Neurons
In order to generate a robust protocol for MEA recording on hiPSC- derived neurons, we evaluated several conditions, which could affect culture performance (1.neuron seeding density; 2.seeding medium; 3.astrocyt eco-culture). These conditions were evaluated with BrainXell’s hiPSC-derived spinal motor neurons, cortical glutamatergic neurons and mixed cortical neurons.
ALS Drug Discovery via High-Throughput Phenotypic Screening Using iPSC-Derived Human Motor Neurons
At BrainXell, we established new technologies to rapidly differentiate ALS patient induced pluripotent stem cells (iPSCs) into large quantities of neurons.
Choosing the Right Parameters for Your UV-Vis Measurement
The Agilent Optimum Parameters Poster is a handy wall chart that provides information about choosing solvents, cuvette types, and managing your instrument parameters.
MALDI Imaging Mass Spectrometry for the Study of Cardiovascular Pathology
Download this poster to learn how a comprehensive MALDI mass spectrometry (MALDI-IMS) approach to formalin-fixed paraffin-embedded (FFPE) tissue samples was developed to study cardiovascular pathology.