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Latest Posters

Poster

MALDI Imaging Mass Spectrometry for the Study of Cardiovascular Pathology

Download this poster to learn how a comprehensive MALDI mass spectrometry (MALDI-IMS) approach to formalin-fixed paraffin-embedded (FFPE) tissue samples was developed to study cardiovascular pathology.
Poster

Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review

This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.

Poster

Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?

Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
Poster

Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against Stroke

We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.
Poster

Comparing The Anti-Alzheimer's Activity of Different Types of Coffee

This study found that coffee solutions treated at 5% are toxic to neurons. However, the toxicity reduced significantly at 2.5%. While the toxicity was significantly less allowing for more cells to survive at 2.5%, the levels of toxic amyloid beta 1-42 significantly reduced. This reduction in amyloid beta is associated with improvement in cognitive performance, as the presence of these toxic peptides is one of the characteristics of AD pathophysiology.
Poster

C1 Complement mediates human cord blood serum derived APP α-secretase cleavage activity in vitro

Our results indicate that CBS contains proteins that promote α-secretase like enzymatic activity. LC-MS/MS analysis in CBSF and AgBSF revealed the presence of 142 proteins of which C1 subunits and alpha-2-macroglobulin showed significantly greater levels in αCBSF compared with αAgBSF. further study showed,C1 subunits can enhance sAPPα production and Aβ reduction in cell culture condition
Poster

A Computational Model of Mood and Future Prospects

Mood disorders are characterized by changes in reaction to positive events, but studies examining mood in gambling have suggested these changes may not be different from control. Interrogating mood changes with a computational model may give insight into disorders like depression.
Poster

Designing a Model to Explore Tau's Unfolded Protein Response

The purpose of this research is to design a cell model in which ER stress caused by tau accumulation can be generated, and then investigated for changes in different ER stress-associated proteins.
Poster

Extracorporeal shockwave therapy accelerates motor axon regeneration despite a phenotypically mismatched environment

A femoral nerve defect model was adapted for the evaluation of proregenerative effects of extracorporeal shockwave therapy (ESWT). Functional evaluation, histology and qRT-PCR data show differences between sensory and motor-derived nerve transplants and a pro-regenerative effect of ESWT. These data provide evidence for the clinical application of ESWT after autologous nerve transplantation as a novel non-invasive method.
Poster

MODEL-AD: The Disease Modeling Project

A summary of the Disease Modeling Project for the MODEL-AD consortium.
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