Neuronal Mislocalization of Mutant DHHC9 in X-Linked Intellectual DIsability
DHHC9 is a protein acyltransferase (PAT) that adds a palmitate to specific protein substrates. In the neuron, palmitoylation of various proteins by DHHC9 facilitates proper neuronal function. Recently, a DHHC9 nonsense mutation (R298*), resulting in a truncation of the last 67 amino acids of the protein, has been associated with X-Linked Intellectual Disability (XLID). Here, we compare neuronal localization of the wild-type (WT) and R298* mutant DHHC9.