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An increase in phosphorylation of tau (hyper phosphorylation) leads to aggregation of the protein resulting in neurofibrillary tangles, a pathological hallmark associated with Alzheimer’s disease (AD). The identification of pharmacological agents that can help decrease levels of phosphorylated tau would be advantageous. Recent work in our laboratory has found that the molecule hexachlorophene can regulate levels of tau in cellular models.

Both oxidative stress and inflammation are involved in the progression of many neurodegenerative diseases, therefore, we examined the potential for AXT to reduced neurotoxicity in a toxic model of PD in mice. Here, we show that administration of algae derived AXT mitigated MPTP induced dopamine cell death.

Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles

The Acoustic Startle Reflex (ASR) is a brain-stem mediated, tri-synaptic response to acoustic stimuli involving involuntary contraction of major muscle groups. Previous studies have demonstrated that this response is suppressed following the fluid-percussion model of traumatic brain injury (TBI). The possibility exists that the suppression of this response could be exploited for prognostic purposes.

Because of the possible beneficial role of polyamines, metabolism of arginine by arginase is of interest. Recently, our lab has recently shown that arginase1 overexpression has the ability to reduce phosphorylated tau and neurofibrillary tangles in rTg4510 and PS19 tau transgenic mice. Based on these data, we utilized the transgenic tetO MAPT*P301L mouse model to examine a potential therapeutic gene of interest, arginase1, in an animal model of tauopathy.

In this study, regulatory T-cells and BMSCs were shown to be neuroprotective following ischemic treatment of primary rat neurons.

In this experiment, we sought to determine the function of hypusinated eIF5a in relation to TDP-43 pathology in nuclear and cytoplasmic compartments under cellular stress.

Profiling of inflammatory cytokines, receptor and kinases in WT and TDP-43 overexpressing mice.

This study is focused on elucidating how tauopathy disrupts normal circadian clock function at both the behavioral and molecular levels.

In this study, we introduce an innovative in silico-based high throughput lead optimization strategy with QSAR and PBPK modelings using StarDrop™, ADMET predictor® and GastroPlus®.