Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review
Poster May 25, 2018
Credit: Collins et al. UCL
Jessica D, Collins, Susie M.D. Henley, Aida Suarez-Gonzalez
Depression, anxiety and apathy are among the most frequent neuropsychiatric symptoms (NS) in typical Alzheimer’s disease, and impact quality of life, risk of institutionalisation, and caregiver burden. However, prevalence in atypical and young-onset phenotypes remains unknown.
This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.