Depressive Symptoms Related to Biological Markers of Immune Functioning among Young People with HIV
Poster Dec 13, 2017
Audra Walsh, PhD, Courtney Lynn, MA, Mercedes Cambric, MA, Carina Rodriguez, MD, Tiffany Chenneville, PhD
Youth living with HIV (YLWH) are at risk for depression. The American Academy of Pediatrics and Health Resources and Services Administration recently released guidelines for Primary Care Providers and Infectious Disease Specialists to screen for depression as part of pediatric preventative healthcare. This study aimed to identify trends in depressive symptoms for YLWH in a specialty-care clinic and follow up clinical treatment procedures. Additionally, this study assessed the relationship between indicators of disease (e.g., viral load, CD4 count) and depressive symptoms. An archival review of a clinical database provided depression screening information for a sample of 115 YLWH between 11-25 years old.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE