Designing a Model to Explore Tau's Unfolded Protein Response
Poster Mar 07, 2018
Lauren Gould, Roy Blackburn, Laura J. Blair
It is known that the accumulation of the protein tau leads to neuronal loss that cause the mental deficits associated with AD. While tau’s relationship with increased neurotoxicity in the brain is known, the method as to how tau triggers the activation of the unfolded protein response (UPR) is unclear and has not been highly explored.
The purpose of this research is to design a cell model in which ER stress caused by tau accumulation can be generated, and then investigated for changes in different ER stress-associated proteins. The data provided by this experiment will allow for a working in vitro model of tau UPR and its effects on ER stress that will allow enhanced understanding of how tau causes neuronal death in AD.
It has become increasingly important for chemists and analysts to be able to test and determine the various components that may be present in mixtures, to solve a wide variety of scientific problems. NMR spectroscopy has emerged as a powerful, non-destructive analytical technique for this.READ MORE
Biologics-based medicines is a rapidly growing field and a promising solution to address many unmet medical needs. Biopharmaceutical developers are actively looking for more efficient and robust production platforms to reduce timelines and overall development costs. Gibco™ Expi™ Expression Systems are complete platforms that can speed up biologics development.READ MORE