Functional, Reprogrammed Microglia To Study Neurodegeneration
Microglia play key roles in neurogenesis, synaptic remodeling, and are the first responders to infection in the brain. Hence, disease-relevant cell models are key to the success of neuroimmune and neurodegeneration research.
Primary microglia are limited in supply, show donor-to-donor variability and can limit the throughput and accuracy of tissue culture experiments. However, precision reprogrammed microglial models developed from human induced pluripotent stem cells (hiPSCs) through precise transcription factor expression now provide a robust and scalable solution to accelerate human brain research.
This poster outlines how hiPSC-derived microglia can be used to study the mechanisms of neurodegeneration with greater accuracy and efficiency.
Download this poster to learn more about:
- Consistent, defined human microglia that are ready to use in 10 days
- iPSC-derived microglia as a model of amyloid beta phagocytosis
- Optimized protocols for microglia/neuron co-culture that accurately model brain function