MALDI Imaging Mass Spectrometry for the Study of Cardiovascular Pathology
Poster Mar 04, 2019
Takashi Nirasawa, Megumi Terada, Hiroko Namba, Nobuto Kakuda, Patrick Bruneval, Hatsue Ishibashi-Ueda and Masaya Ikegawa.
Cardiac Amyloidosis represents a growing number of diverse and devastating diseases which comprise cerebral forms such as Alzheimer's disease and cerebral amyloid angiopathy. These diseases are characterized by the aggregation of normally soluble, natural proteins or their fragments into highly ordered amyloid fibrils that deposit in target organs leading to dysfunction.
This poster highlights how a comprehensive MALDI mass spectrometry (MALDI-IMS) approach to formalin-fixed paraffin-embedded (FFPE) tissue samples was developed to study cardiovascular pathology.
Download this poster to learn: -
- How a MALDI-IMS protocol for FFPE samples of human cardiac biopsy was established
- How typing cardiac amyloidosis from FFPE samples can be achieved with MALDI-IMS
When there is a need to quickly analyze samples using a number of different PCR assays, it is likely that optimal conditions for each assay will not be the same. First, different assays often will require different annealing temperatures for their primers. In addition, amplicons may be designed to be of different lengths and therefore require varying durations of the extension step.READ MORE
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