MEG Resting State Functional Connectivity and Network Topology in Dyslexia Related Genotype
Poster Sep 12, 2017
D. Brkić1, J.B. Talcott1 , A. Hillebrand2 , S. Paracchini3& C. Witton1
1Aston Brain Centre, School of Life & Health Sciences, Aston University, Birmingham, UK 2Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands 3 University of St Andrews, St Andrews, UK
One dyslexia candidate gene-PCSK6- has recently been proposed to provide a molecular link between brain asymmetry, handedness and reading impairment.
Studying resting state neuro-functional interactions and their network distribution may tell us more about differences in typical and a typical brain development.
Combining neuroimaging techniques and genetic information may provide a powerful means to investigate the biological basis of reading delay.
Here, we used a MEG source-space method and Minimum Spanning Tree sub-graph to investigate resting state functional connectivity and topology in children with diagnoses of dyslexia with and without PCSK6 genetic risk.
1.Shore et al. (2016) Human Molecular genetics
2.Hillebrand et al. (2012) Neuroimage, 59 (4)
3.ASEBA questionnaires (www.aseba.org)
4.Stam et al. (2014), Int. Journal of Psychophysiology
5.Nichols & Holmes (2001), Human Brain Mapping
6.Zhou et al. (2015) Frontiers, volume 9
This poster was presented at American Association of Clinical Chemistry
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE