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Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes
Poster

Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes

Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes
Poster

Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes

This poster presents our results to date using clozapine (a compound known to be associated with GSH-adduct formation) as substrate and using stable isotope GSH (GSH13C2,15N) to enhance specificity. In addition, all analyses have been conducted using an Waters Acquity UPLC-MS/MS. Results we have obtained in hepatocytes are compared against findings using human liver microsomes (HLM).
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