Role of TDP-43 in activation of the brain inflammatory response

TDP-43 is associated with fronto-temporal lobar dementia (FTLD) and some cases of Alzheimer’s disease. Previous studies have found a role for TDP-43 in regulation of inflammatory markers such as IL-6, but the effect of increased TDP-43 expression on inflammation has not been studied. In order to fill these gaps, we induced peripheral inflammation in WT and TDP-43 overexpressing mice and began profiling changes in inflammatory cytokines, receptors, and kinases, in addition to changes in behavior.