AnaSpec Introduces new Selection of RGD GO™ Peptides
Product News Mar 08, 2010
As part of its GO™ Peptides collection, AnaSpec has introduced a selection of cyclic and non-cyclic RGD peptides.
The RGD (Arg-Gly-Asp) tripeptide motif can be found in extracellular matrix (ECM) proteins such as fibronectin, fibrinogen, prothrombin, tenascin, thrombospondin, vitronectin, von Willebrand factor, Adenovirus penton base protein, bone sialoprotein, collagen, decorsin, disintegrins.
The exposed RGD motif constitutes a major recognition site for integrin binding. Integrin, a transmembrane heterodimeric protein, is an adhesion protein consisting of an alpha and a beta subunit. Interaction of integrin with ECM proteins modulates vital bidirectional signals during morphogenesis, tissue remodeling and repair. A well-studied interaction between integrin and ECM protein is that of avb3 integrin with Fibronectin (FN), a major ECM protein.
This interaction modulates processes such as cell migration, adhesion and angiogenesis 5-6 FN contains FNIII repeats, with pockets of RGD. Synthetic cyclic RGD peptides have been found to be selective and potent avb3 integrin antagonist resulting in inhibition of angiogenesis.