We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Amyloid Precursor Protein and Aß Detection from BioLegend

Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Amyloid Precursor Protein and Aß Detection from BioLegend"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Amyloid Precursor Protein (APP) is a type-I transmembrane protein with enriched expression in neuronal tissues. APP undergoes sequential proteolytic processing through two distinct pathways: 1) the amyloidogenic pathway that generates Amyloid Beta (Aβ) and 2) the non-amyloidogenic pathway that precludes the generation of Aβ. Aβ is generated when APP is cleaved by β-secretase, followed by cleavage from γ-secretase, while APP cleavage by α-secretase followed by γ-secretase does not generate Aβ peptide. The amyloidogenic pathway is associated with an accumulation of the neurotoxic Aβ peptide and is associated with Alzheimer's, Parkinson's, and other neurological diseases. BioLegend is proud to provide BetaMark™ ELISA Kits for the detection of key proteins associated with APP/beta amyloid processing.


Visit the APP webpage for further information