AnaSpec Offers a & ß-Synuclein Recombinant Proteins
Product News Jan 25, 2011
AnaSpec, Eurogentec Group, offers two recombinant proteins for use in Neurodegenerative Disease Research, α-synuclein (SNCA) and β-synuclein (SNCB). Both α-synuclein and β-synuclein are expressed and purified from E. coli. α-Synuclein is a 140-amino acid long recombinant protein and β-synuclein is 134-amino acid long.
α-Synuclein (SNCA) and β-synuclein, along with γ-synuclein (SNCG), are members of the synuclein family of small proteins expressed primarily in neural tissue and in some tumors. Synuclein proteins, found only in vertebrates, possess a highly conserved N-terminal domain, with a variable number of 11-residue repeats and a less conserved C-terminal, with a preponderance of acidic residues.
α-Synuclein is used in Parkinson’s disease (PD) research, and β-synuclein has been shown to induce mild experimental autoimmune encephalomyelitis (EAE) in Lewis rats. These proteins can be used in applications such as ELISA, western blots and microscopy imaging.