BIOCRATES Life Sciences AG Launches new Analytical Method for Functional Microbiome Research
Product News Nov 07, 2018
IOCRATES Life Sciences AG, a global leader in metabolomics, announced the introduction of MxP® Quant 500. This new, comprehensive analytical method enables the quantitative measurement of a large number of different metabolites produced by intestinal bacteria. MxP® Quant 500 will provide researchers with new insights into the highly interesting interaction between the body and the intestinal bacteria known as the microbiome.
The metabolite profiles obtained with MxP® Quant 500 can be correlated with different diseases and provide new information on which metabolic pathways are important in the manifestation and progression of cancer, diabetes and neurological diseases such as Parkinson's or Alzheimer's disease.
“Intestinal bacteria have a great influence on human health and well-being. However, their function is still barely understood. The genomic identification of intestinal bacteria is not sufficient to understand their effect in our body,” commented Dr. Wulf Fischer-Knuppertz, CEO of BIOCRATES. “The bacteria in the digestive tract produce a large number of substances that are absorbed by the body and have a variety of effects.”
The new MxP® Quant 500 Kit covers a unique spectrum of metabolites. It can be used to determine metabolic products in blood and stool, including hundreds of metabolites produced by the body as well as substances modified by the microbiome such as choline and its degradation products, branched-chain amino acids and secondary bile acids. Such metabolic profiles will play an important role in the diagnostics of the future and can thus make a valuable contribution to truly personalized medicine.
“In many diseases, the interaction of our body with the microbiome is of immense importance. Our new kit produces a unique snapshot that captures these dynamics and makes them tangible,” added Dr. Fischer-Knuppertz. “Our new analysis method shines light into this large 'black box’.”
The important role of the substances produced by the microbiome is already known for some diseases. The relationship between nutrition, obesity and diseases such as diabetes, cardiovascular and even neurological diseases such as Parkinson's, multiple sclerosis and Alzheimer's, is the subject of intensive research. For example, a recently published study associates an altered bile acid profile with cognitive impairment in Alzheimer's disease.
Our immune system and the effect of drugs also seem to be influenced by the individual microbiome. In high-ranking scientific journals, the influence of the microbiome on our immune system and the effect of drugs is currently being discussed extensively. In a study published in Science, it was shown that changes in the intestinal flora caused by antibiotics significantly changed the response to cancer therapy.
With the help of MxP® Quant 500 Kit, scientists areenabled to find out which processes trigger these effects and how they can be specifically harnessed.