Synaptic Function Antibodies from BioLegend
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Neurons are designed to transmit electrical and chemical signals through specialized cellular projections—axons and dendrites—that extend far from the cell body. This relay of signals occurs at the neural synapses between the axon of one neuron and the dendrites of another. It is composed of hundreds of proteins and aids in higher nervous system functions, such as cognition, memory, or movement.
Synapses adapt over time and can weaken or strengthen in response to a number of factors. Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, display a loss of synaptic function and a subsequent degradation of these structures. This phenomenon is more prominent at particular locations in the central nervous system for some neurodegenerative diseases, such as the substantia nigra for Parkinson’s disease, which is highly enriched in synapses that transmit the neurotransmitter dopamine.
Investigation into the mechanisms that lead to dysfunction and synaptic loss, with the support of BioLegend reagents, may provide new avenues for preventative or therapeutic intervention.