Tau Proteins, Isoforms, Antibodies
In neurons, Tau (MAPT - microtubule-associated protein tau) is a protein that binds to microtubules (the neuron’s transport system), which stabilizes their formation and maintenance. Tau is alternatively spliced into six isoforms in the human central nervous system. The hyperphosphorylation of the tau protein reduces its binding affinity to microtubules, thus disrupting the structural organization and maintenance. Excess levels of unbound tau protein leads to the formation of tau aggregates, insoluble fibrils, and intracellular neurofibrillary tangles observed in Alzheimer’s disease (AD) and other tauopathies. BioLegend is proud to offer a wide range of high quality, well-characterized products to support research into the mechanism of neurological processes and implications in neurodegenerative diseases.