Ubiquitin Detection Antibodies from BioLegend
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Ubiquitin is small protein of 76 amino acids that is highly conserved among species. Ubiquitination is a process whereby ubiquitin is activated by ubiquitin-activating enzymes (E1) and covalently attached to protein substrates by ubiquitin-conjugating enzymes (E2) and ligases.
The type and number of ubiquitin linkages (mono-, multi- and poly-ubiquitin) serve as a signal for different fates such as protein endocytosis and degradation. In the brain, ubiquitination is involved in many cellular processes including development, maintenance and remodeling of synaptic connections.
Many synaptic proteins such as neurotransmitter receptors and scaffold proteins are targets for ubiquitination. In addition, defects in ubiquitin-mediated processes are linked to neurodegenerative disorders such as Alzheimer’s disease.
BioLegend offers high-quality antibodies for detection of mono- and poly-ubiquitin, E1s and ligases.