Wyatt Technology Announces its Möbiu?™ Mobility Instrument at Pittcon 2010
Product News Mar 09, 2010
Wyatt Technology Corporation announced the launch of its Möbiu?™ mobility instrument on booth #972 at Pittcon 2010, being held February 28 -March 5, in Orlando. The instrument incorporates several patent-pending innovations to realize measurements of macromolecular electrophoretic mobilities.
Besides being capable of measuring mobilities of large particles such as liposomes and VLPs, Wyatt Technology’s Möbiu?™ is the only laser-based instrument that achieves reproducible measurements of traditionally challenging protein samples including antibody formulations, bovine serum albumin and lysozyme. It is designed specifically to address the measurement of protein mobilities rather than a remake of a device designed to measure particulates.
Wyatt Technology’s Möbiu?™ allows massive parallelism of detection and extends the measurable molecular size range below 2 nm. A reduced measurement time contributes to preservation of precious and fragile protein samples.
In a specific example, Size Exclusion Chromatography (SEC) corroborated the preserved integrity of a sample of monoclonal antibody after the mobility measurement. A sample recovery rate of >98% was obtained. Another important advantage of Wyatt Technology’s Möbiu?™ which results from the patent-pending detection process is its much increased detection sensitivity: 2 mg/mL lysozyme or 0.5 mg/mL BSA. This represents an order of magnitude greater sensitive than the closest competitor.
Simultaneous measurement of the macromolecular hydrodynamic radius is available with the WyattQELS option, which utilizes backward scattered light to determine the sample translational diffusion coefficient. Both reusable flow-through cells and disposable cells are offered for mobility (and QELS) measurements. Samples can be introduced by manual injection, an auto-sampler, syringe pump or an auto-titrator. The Möbiu?™ also has temperature control capability and is able to perform automated temperature studies.