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Featured Product

ioAstrocytes - Human iPSC-Derived Astrocytes

ioAstrocytes are functional human iPSC-derived astrocytes, deterministically programmed using opti-ox™ technology that convert consistently into defined astrocytes within days. Cells demonstrate expected stellate morphology, express key astrocytic markers (SOX9, EAAT1, S100B and Vimentin), are capable of phagocytosis, cytokine secretion, and modulation of neuronal activity in co-culture.

Early access product now available, contact us for more information.

ioAstrocytes are designed for ease of use, delivered cryopreserved and supported by open-source media and protocols to be cultured with other CNS cell types such as ioGlutamatergic Neurons.

The cells recapitulate key human astrocytic functions, including mediating an inflammatory response, disposal of unwanted materials and modulation of neuronal activity in co-cultures. Multiple lots of cells were investigated by bulk-RNA sequencing, each displaying highly equivalent transcriptomic profiles, with less then 0.5% differentially expressed genes, enabling scientists to generate reproducible data, consistently.

ioAstrocytes bridge translational gaps and overcome limitations associated with the generation of accurate in vitro models of the human brain, to support neurodegenerative disease research and therapeutic development.

Product Specifications
Staring Material Human iPSC line
Donor Caucasian adult male (skin fibroblast)
Differentiation Method opti-ox deterministic cell programming
Format Cryopreserved cells
Seeding Compatibility 6, 12, 24, 96 and 384 well plates
Vial Size Small: ≥1 x 10⁶ viable cells
Recommended Seeding Density 30,000 cells/cm²
Product Use ioCells are for research use only
Shipping Info Dry ice
User Storage LN2 or -150°C
About bit.bio
bit.bio is an award-winning human synthetic biology company whose mission is to code cells for novel cures. They have developed an end-to-end platform for the creation of any human cell type. With their cutting-edge and patent-protected opti-ox<sup>™</sup> precision cell programing technology, bit.bio can deterministically program human induced pluripotent stem cells (iPSCs) into a chosen cell identity with unprecedented biological consistency at an industrial scale and approximately 10 times faster than conventional methods. Their platform has the potential to unlock a new generation of medicines.
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