Advanced Cell Models – News and Features

Researchers have created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models accurately replicate human brain development.

A study reveals that intestinal tuft cells can proliferate and survive radiation damage, acting as reserve stem cells that regenerate damaged intestinal tissue. Researchers demonstrated tuft cells' significant role in intestinal epithelium repair.

A study demonstrates that human embryonic stem cell-derived retinal organoid sheets effectively closed macular holes in a monkey model. The transplantation promoted the survival and maturation of retinal tissue.

Researchers have made a significant step towards enabling women with epilepsy safer access to a common and highly effective anti-seizure medication.

A study has revealed two distinct molecular subtypes of Crohn’s disease using organoids from adult stem cells, allowing for better understanding of the disease's mechanisms. The findings suggest treatments should be tailored based on these subtypes.

Researchers at Johns Hopkins examined human bioengineered heart tissues sent to the International Space Station. They found that low gravity weakened the tissues, causing reduced strength and irregular beats compared to Earth-bound samples.

A UCLA team created a biobank of sarcoma organoids from 126 patients, enabling rapid drug screening. The organoids retained tumor characteristics, allowing identification of effective FDA-approved treatments for 59% of samples.

Scientists can now directly compare the different kinds of injury that mechanical ventilation causes to cells in the lungs, with shear stress from the collapse and reopening of the air sacs being the most injurious type of damage.

A study shows that SARS-CoV-2 triggers immune cells to destroy insulin-producing beta cells, potentially inducing diabetes. Researchers used pancreatic tissue from COVID-19 patients and innovative organoid models to uncover this mechanism.

A groundbreaking 3D organoid culture method has been developed for generating large numbers of muscle stem cells in vitro.