Molecular Elucidation and Engineering of Stem Cell Fate Decisions


Molecular Elucidation and Engineering of Stem Cell Fate Decisions
David Schaffer
Professor and Director

As the field progressively learns more about the mechanisms that control stem cell behavior – in particular their two hallmark properties of self-renewal and differentiation – deeper insights are gained into their potential roles and applications in organismal development, adult homeostasis, and regenerative medicine. The niches in which stem cells reside present them with a spectrum of signals to control their behavior, and it has become increasingly evident that not only are local biochemical signals important, but biophysical features of the environment that modulate the presentation of this biochemical information can impact cell behavior.

We have created several technology platforms to investigate the biophysical regulation of stem cell behavior, in particular to understand and control the differentiation of adult neural stem cells and human pluripotent stem cells into neurons.

Attend this webinar to learn:

Stem cells are regulated by signals from their environment
New technologies are advancing biochemical and biophysical understanding of stem cell regulationn
Mechanics, spatial patterning of signals, and temporal fluctuations in cues – can strongly impact cell behavior


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