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10 Things We Didn't Know Last Week, September 21, 2018

List

10 news stories from across the world of science guaranteed to make you sound more interesting

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Designing Proteins Bit by Bit

Blog

Cell-Free Technology is taking a unique approach to protein technology with their BioBits initiative, which they say combines the ease of use of a digital design tool with the detailed scientific validation provided by a CRO. We catch up with Cell-Free CEO Tom Meany to discuss the new technology.

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A Dynamic Protein Atlas of Human Cell Division

News

A new 4D computational model which integrates CRISPR, confocal microscopy, and machine learning allows researchers to study the dynamics of specific proteins which drive mitosis. The model is a framework which can be adapted to study other cellular functions.

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Gene Screen Predicts Bone Fracture Risk

Gene Screen Predicts Bone Fracture Risk

News

A new genetic screen may be able to predict low bone-mineral density, osteoporosis and fracture risk prior to clinical symptoms, according to a retrospective study of nearly 400,000 people by a Stanford researcher.

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Ovarian Cancer Biomarker Can Predict Patient Therapy Response
News

Researchers have identified an independent prognostic factor - cancer/testis antigen 45 (CT45) - and have begun to elucidate it's actions. CT45 is associated with extended disease-free survival for women with advanced ovarian cancer.

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Exposing the Exposome
News

Stanford scientists have measured the human “exposome,” or the particulates, chemicals and microbes that individually swaddle us all, in unprecedented detail.

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How the Cell Copes With Stress
News

Researchers from the Department of Biochemistry and Molecular Biology at the UAB and from the United Kingdom, for the first time describe the mechanism used by cells to optimise protein production in stressful situations through the altering of tRNA abundance.

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Three Ways to Turn Life Science Suppliers into Partners
Three Ways to Turn Life Science Suppliers into Partners
Article

A growing number of life science businesses are turning to greater supply chain collaboration for benefits like accelerated time to market, improved quality, reduced risk and more rapid and widespread innovation. But while 68% of executives in this industry say active and meaningful engagement with suppliers is essential to success, far too many, over a third, struggle to implement it.

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Deciphering the Cancer Proteome
Deciphering the Cancer Proteome
Article

This article explores the current state of play within the area of cancer proteomics, highlights some of the techniques used to investigate the proteome, and looks at the impact of combining proteomics with other ‘omics’ in relation to cancer research.

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Procalcitonin Measurement for Effective Antibiotic Stewardship
Procalcitonin Measurement for Effective Antibiotic Stewardship
Article

The accurate identification of bacterial infections is necessary for the fight against antibiotic resistance. This procalcitonin assay is set to aid antibiotic stewardship and improve healthcare outcomes for sepsis patients.

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Antimicrobial Resistance – the Rise of Global Superbugs
Antimicrobial Resistance – the Rise of Global Superbugs
Article

Antimicrobials have revolutionized medicine by enabling treatments for diseases that would once have proven fatal, however,they have since proven to be a double-edged sword.

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Scientist Explains How They Un-picked Pick’s Disease
Scientist Explains How They Un-picked Pick’s Disease
Article

Scientists use Cryo-EM to solve the structure of the frontotemporal dementia-causing tau protein tangles.

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Cancer Biomarkers: the Liquid Biopsy Revolution
Cancer Biomarkers: the Liquid Biopsy Revolution
Article

Non-invasive liquid biopsies are set to change the landscape of how cancers are diagnosed and treated in the future. We explore how mass spectrometry is helping researchers discover protein biomarkers in blood and urine, highlight challenges around their validation – and find out how close they are to reaching the clinic.

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