Proteomics and Cancer: a Powerful New Revolution

Article

In the post-genomics era, we look at the powerful new revolution in proteomics. We find out how advances are deepening our understanding of cancer biology and resistance processes, which will lead to new clinical applications such as non-invasive biomarkers and drug development.

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Reversing an Unstoppable Cancer Cascade with Proteomics

Reversing an Unstoppable Cancer Cascade with Proteomics

News

Mutations in genes that produce RAS proteins turn a normally benign process, essential for cellular growth, into a cancer stimulant that is currently undruggable. Now, cutting-edge protein analysis may help treat cancers caused by these mutations.

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Understanding Inflammation From the Inside Out
News

Researchers have developed a method that enables them to genetically modify immune cells, multiply them and visualize them in living organisms. The technique will better evaluate and study the the inflammatory process.

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Mechanism That Enables Avian Flu Viruses to Infect Humans Discovered
News

A team of investigators has found a new mechanism that is critical to the ability of certain avian influenza A viruses to infect humans. The mechanism overcomes a defense that normally protects human cells from infection by avian influenza.

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Of Mice and Disease: House Mice Carry Bacteria Responsible for Food Poisoning
News

A Study of mice from apartment buildings showed that many carry bacteria responsible for mild to life-threatening gastroenteritis in people, and some of these bacteria may be resistant to antibiotics.

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Unease on the High Seas: The Effect of Climate Change on Marine Microbial Ecology
Unease on the High Seas: The Effect of Climate Change on Marine Microbial Ecology
Article

Microbes play an important role in the marine ecosystem, however, the effects of climate change have the potential to upset this fine balance, leading to increasing issues with cyanobacterial blooms. Exciting work seeks to look at the knock on effects on the marine food web and ways to combat these toxic blooms.

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Blood Tests for Brain Diseases
Blood Tests for Brain Diseases
Article

Definitive diagnosis for many neurodegenerative diseases – such as Alzheimer’s, Parkinson’s, or Chronic Traumatic Encephalopathy (CTE) – frequently comes far too late. The “true gold standard” for diagnosis of both Alzheimer’s and CTE is through direct postmortem examination of brain tissue. Now, both researchers and athletes are working to change that.

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Exploiting Exosomes for Cancer Diagnosis and Treatment
Exploiting Exosomes for Cancer Diagnosis and Treatment
Article

Evidence is mounting for exosomes playing a central role in many aspects of cancer biology. As researchers start to unravel the secrets of these elusive little vesicles, this is opening a host of exciting new opportunities to tackle cancer – from non-invasive diagnostics to innovative new therapeutics.

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Are Carbon Nanotubes a New Asbestos?
Are Carbon Nanotubes a New Asbestos?
Article

Used in myriad applications and showered with praise by researchers, carbon nanotubes (CNTs) are hailed as a "wonder material" for materials science. This lofty position may be jeopardized by a new study that shows CNTs can induce the fatal cancer mesothelioma in the same way as asbestos.

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Making Laser Spectroscopy Portable for On-Site Food Safety Tests
Making Laser Spectroscopy Portable for On-Site Food Safety Tests
Article

Those involved in the production, processing and distribution of food know that food safety is not an issue to be taken lightly. Of note, mycotoxins in food are subject to strict legislative limits and therefore their detection and quantification are a key area of interest.

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Molecular Physiome of Brain Regions Identified Using Top-Down Proteomics and MALDI Imaging Mass Spectrometry
Molecular Physiome of Brain Regions Identified Using Top-Down Proteomics and MALDI Imaging Mass Spectrometry
Article

Team develops novel strategy combining MALDI-IMS and spatially-resolved top-down proteomics to investigate differences in protein expression at the cellular level, in brain tissue.

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