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Metabolomics: The Long Journey from Lab to Clinic

Article

Recent improvements in technology are enabling the simultaneous detection and quantitation of large numbers of metabolites from biological samples. Here, we examine the challenges and innovations in metabolomics technologies and find out how these tools are impacting on clinical biomarker discovery.

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From Metabolite to Biomarker: Mass Spectrometry in Diagnostics

Article

Professor Alain van Gool, Professor of Personalized Healthcare at Radboud University Medical Center (Radboudumc), in Nijmegen, The Netherlands, helps oversee Radboudumc’s 19 Technology Centers, which span multiple aspects of biomedical science. He also has a rather more specialized position as head of the Translational Metabolic Laboratory (TML).

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What Makes Good Brain Proteins Turn Bad?

What Makes Good Brain Proteins Turn Bad?

News

The protein FUS is implicated in two neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Using a newly developed fruit fly model, researchers have zoomed in on the protein structure of FUS to gain more insight into how it causes neuronal toxicity and disease.

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‘Good Cholesterol’ May Not Always be Good for Postmenopausal Women
News

Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) – also known as ‘good cholesterol’ – according to a study led by researchers in the University of Pittsburgh Graduate School of Public Health.

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Bad Teeth Put to Good Use
News

Researchers analysing the teeth of Britons from the Iron Age to the modern day have unlocked the potential for using proteins in tooth tartar to reveal what our ancestors ate.

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Working Together Helps Phage Overcome CRISPR
News

Surprising results show that phage join forces to overcome bacteria’s CRISPR -based immune defenses. Improved understanding of the interactions between phage and their bacterial hosts could help advance phage-based therapies and stimulate viral research.

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Cell Culture Quality Control: Blissful Ignorance?

Cell Culture Quality Control: Blissful Ignorance?

Article

How can quality control efforts keep up with the rapid advances in cellular model research? Read on for insights into challenges in recognizing and managing issues in cell culture quality control

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UPS Ensures a Stable Outlook for Diamond Light Source
Article

Diamond Light Source is the UK's national synchrotron facility and is used by over 7,000 researchers from both academia and industry to conduct essential experiments that keep the UK at the forefront of scientific research. Due to the sensitive nature of the equipment, it is therefore imperative that a stable power supply is maintained to the equipment.

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Biosafety and the Agents of Doom
Article

To combat harmful pathogens it is vitally important that scientists have facilities available that enable them to work on them safely. These facilities should prevent the operator from becoming infected with the agent they are working with and prevent the organism from escaping the laboratory setting and potentially initiating new outbreaks of disease.

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Strawberry’s Properties are More than Skin Deep
Article

Everyone loves a perfectly ripe strawberry, right? They count towards your five a day and contain important nutrients, vitamins and antioxidants. But what if science could help breeders make them even better?

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