A new technique called ECCITE-seq allows researchers to perform high-throughput measurements of multiple modalities of information from single cells.

Using EBX reagents, researchers have converted the C-terminal carboxylic acid of peptides into a carbon-carbon triple bond - an alkyne (in chemical jargon a "decarboxylative alkynylation"). The alkyne moiety is a very valuable functional group that can be used to further modify the peptides.

A process that cells use to unravel knotted strands of DNA - resembling a method used to control climbing ropes - has been uncovered by scientists.

Using a unique computational "framework" they developed, a team of scientist cyber-sleuths has identified 104 high-risk genes for schizophrenia.

Scientists have used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence.

A research team have developed a method to detect the amyloid-beta (Aβ) peptide in human blood. They hope that their research will have implications in diagnosing and understanding the progression of Alzheimer's disease (AD).

Given the complexity of cancer, it’s arguably unlikely that single molecules will work as clinically meaningful biomarkers for cancer. Today, biomarker discovery involves detecting patterns – characteristics or phenotypes that can be measured and monitored throughout a patient’s journey. Here, we look at two approaches being explored in this evolving field.

When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results you are obtaining are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow you to evaluate just that.

Identical male twins Scott and Mark Kelly - both (now retired) NASA astronauts – spent one year apart as Scott travelled to and inhabited the International Space Station (ISS), whilst Mark stayed at home on earth. Researchers have gained valuable insights from the study results as to the physiological effects of space travel.

Part of the "systems biology" trend, proteogenomics is expanding at an accelerating rate. In this article, we look at the approaches adopted in proteogenomics and explore how proteogenomics is changing the dynamics of precision medicine in oncology.

This article provides insights on the impact of post-translational modifications of biopharmaceutical products on drug development and biotherapeutic formulation.

From picking out cancerous tissue areas during diagnosis, to uncovering novel biomarkers of early detection, mass spectrometry has become an indispensable analytical technique in cancer research.