Discovery vs Targeted Proteomics

Infographic

Currently, modern proteomics research using Mass Spectrometry (MS) is split between discovery and targeted assays. This infographic includes workflows for the two techniques and will examine the advantages and disadvantages of each method. Finally, common applications of each technology will be explored, and we will look to a future where the division between targeted and discovery methods might not even be required.

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Accelerating Proteome Analysis With PASEF: A Unique and Sensitive Technique

Blog

Understanding the proteome is a fundamental challenge of biology. Here, Bruker Daltonics' Gary Kruppa and Scarlet Koch outline a new method, Parallel Accumulation Serial Fragmentation (PASEF) that offers faster, more sensitive and more robust proteome analysis, giving scientists the potential to discover low-level, biologically significant proteins and validate them in research.

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10 Things We Didn't Know Last Week - 18 May 2018

List

The most exciting science new stories from the last 7 days

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10 Things We Didn't Know Last Week - 11 May 2018

List

The most exciting science from the last 7 days

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A New Generation of Flow Cytometers Advances Multiomics

Blog

Flow cytometry allows the analysis of physical and biochemical features of cells. Advances in machine that can characterize and sort cells will allow researchers to look deeper than ever before into the proteome and transcriptome. We talk with Bob Balderas, VP Market Development at BD on how the cutting-edge machines like the FACSymphony S6 cell sorter incorporate new technology and advance multiomics research.

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Simple Sugar Prevents Neurodegeneration in Lysosomal Storage Disease
Simple Sugar Prevents Neurodegeneration in Lysosomal Storage Disease
News

New therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB)

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Eating Activates Calorie-Burning Fat
Eating Activates Calorie-Burning Fat
News

The importance of the human brown adipose tissue (BAT) has become clearer during the past ten years. Coldness is one of the most effective activators of the BAT metabolic function but, in rodents, eating has also been shown to activate BAT. The debate on whether eating has the same effect on humans has lasted for decades. Now, the researchers at Turku PET Centre have proven that having a meal increases oxygen consumption in human BAT to the same extent as coldness.

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Protein Turnover Rates Differ Across the Brain
Protein Turnover Rates Differ Across the Brain
News

Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are.

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Algorithm Helps Diagnose Zika Using Biomarkers
Algorithm Helps Diagnose Zika Using Biomarkers
News

A platform that can diagnose several diseases with a high degree of precision using metabolic markers found in patients’ blood has been developed by scientists at the University of Campinas (UNICAMP) in Brazil.

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Mechanism by Which Alpha Synuclein Causes Cell Death in Parkinson's Identified
Mechanism by Which Alpha Synuclein Causes Cell Death in Parkinson's Identified
News

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease.

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Improved Method for Isolating Extracellular RNA
Improved Method for Isolating Extracellular RNA
News

In a breakthrough that could lead to powerful new ways to diagnose and track a wide range of medical conditions, scientists at The Rockefeller University have devised an improved method for isolating and identifying tiny fragments of RNA in human blood products.

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Scientists Explore the Molecular Mechanics that Drive us to Sleep
Scientists Explore the Molecular Mechanics that Drive us to Sleep
Article

Scientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles

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Cryo-EM and CX-MS: The Power Couple of Proteomics
Cryo-EM and CX-MS: The Power Couple of Proteomics
Article

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

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Sensitive Quantification of Drug Metabolites Using LC-MS
Sensitive Quantification of Drug Metabolites Using LC-MS
Article

Determining what happens to a drug after it enters the body is a key consideration in the drug development process. Liquid chromatography coupled with mass spectrometry (LC-MS) has emerged as one of the most powerful analytical tools for the screening and identification of drug metabolites. Advances in the field of LC-MS have allowed scientists to analyze drug metabolic pathways and drug-drug interactions more closely, and improve therapeutic strategies for many challenging diseases.

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The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
Article

Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could result in more successful telomerase-related clinical therapeutics.

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Tech Solutions for Drinking Water Analysis
Tech Solutions for Drinking Water Analysis
Article

Improved access to clean and safe drinking water is key for health and survival and has been classified as a human right. Here, we take a look at some of the novel solutions, both hi-tech and low-tech, that scientists are designing to help monitor drinking water source safety.

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 Proteomics and Cancer: A Powerful New Revolution
Proteomics and Cancer: A Powerful New Revolution
Article

In the post-genomics era, we look at the powerful new revolution in proteomics. We find out how advances are deepening our understanding of cancer biology and resistance processes, which will lead to new clinical applications such as non-invasive biomarkers and drug development.

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