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Latest Application Notes

Application Note

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Preparation

Download this free application focus to learn more about how Agilent's latest RapidFire 400 mass spectrometry system.
Application Note

Guide RNA Production

Over the past decade there has been a widespread adoption of CRISPR/Cas9-based methods for genome editing in biological systems ranging from cultured cells to entire animals.
Application Note

Label-Free Single Cell Proteomics Workflow

Label-Free Single Cell Proteomics Workflow With the CellenONE Platform and the TimsTOF SCP
Application Note

Get a High-Resolution View of Your Lipid Nanoparticles

Lipid nanoparticles (LNP) play a key role in effectively protecting and transporting mRNA to target cells in mRNA-based vaccines and therapeutics. To ensure the quality and safety of LNP, lipid components and associated impurities/degradants need to be carefully characterized in raw materials and formulation.
Application Note

TIMScore With PaSER: Exploiting the CCS-Dimension

Download this app note to discover a solution that boosts the numbers of proteins, peptides and PSMs in complex datasets as well as increases protein sequence coverage substantially.
Application Note

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities.
Application Note

A Tale of Two End-to-End Targeted Metabolomics Workflows

Download this application focus to learn more about two novel, sensitive, targeted metabolomics solutions.
Application Note

Phosphorylated Peptide Post-Translational Modification Site Localization and Isomer Differentiation

However, PTM site localization and quantification of phosphopeptides by collision induced dissociation MS/MS can be challenging, and phospho-peptides can exhibit a partial neutral loss of the phospho group.
Application Note

Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.
Application Note

Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.
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