Latest App Notes & Case Studies

Bile acids are well known for their roles in cholesterol homeostasis, lipid absorption and as metabolic signaling molecules. They are implicated in a variety of disease states and therefore serve as an exciting focus on research in novel biomarker discovery.

Pluripotent stem cells are the gateway to creating cells for disease modeling, regeneration and drug discovery. When it comes to growing such infinite potential, selecting the right culture medium is key!

Identifying novel biomarkers with bottom-up proteomics remains a substantial challenge due to the wide concentration ranges and potentially low abundance of important analytes.

Need a routine analytical technique that can provide protein expression profiling and targeted drug imaging? MALDI Imaging is used to determine the spatial distribution of molecules in a tissue section, for more complete multiomic information.

Lipid nanoparticles (LNPs) have emerged as effective delivery vehicles for mRNA vaccines and nucleic acid-based drugs. Hence, the analysis of their composition, stability, and biological interactions is essential in drug development and delivery.

A major challenge preventing transformative gene therapies from reaching patients is the lack of fit-for purpose potency assays, which are some of the most important assays in an analytical package but are often the most complex and high-risk.

While depleting abundant proteins can facilitate the detection of low-concentration biomarkers, such methods can be labor-intensive, costly and can result in sample loss. Discover how parallel accumulation, serial elution and fragmentation (PASEF) can support researchers to achieve accurate large-scale plasma proteomics.

Discover an automated solution for the consolidation and ranking of your metabolite structures. Explore a workflow that utilizes both EAD and CID data for the most confident characterization and streamlined data acquisition.

Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells.