Latest App Notes & Case Studies
App Note / Case Study
Going Library-Free for Protein Identification
Download this app note to discover a SWATH DIA workflow that:
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow
App Note / Case Study
Ensuring Quality Control of IVT RNA Workflows
This tech note highlights technology that switches easily between DNA and RNA analysis to ensure quick and reliable quality checks and precise sizing of DNA and IVT RNA products.
App Note / Case Study
High Resolution Mapping of the Breast Cancer Tumor Microenvironment
Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.
App Note / Case Study
Fast and Accurate Protein Quantitation
Protein quantitation is an integral part of many protein biology workflows and a necessary step before commonly used techniques such as protein electrophoresis, western blotting, mass spectrometry and immunoassays.
App Note / Case Study
Analyzing Complex Spatial Data for Deep Insights
The MACSima™ Imaging Platform is based on a highly multiplexed spatial proteomic technology providing a tremendous amount of complex data. MACS® iQ View – the integrated, easy-to-use analysis software – allows users to evaluate the spatial relationships of expressed markers and gain deep insights.
App Note / Case Study
Rare Cell Discovery With a High-Plex Imaging Platform
Rare cells play pivotal roles in disease initiation, maintenance and progression. Yet, identifying these cells remains a difficult task for low-plex technologies, as it is not always clear a priori which biomarkers distinguish rare phenotypes from the remaining population.
App Note / Case Study
A Novel Data Processing Workflow for Isotope Tracing Experiments in LC-MS
On the frontier of metabolic pathway analysis and fluxomics research, LC-MS and LC-TIMS-MS based isotope tracing experiments offer the opportunity to detect and quantify the incorporation of isotopically labeled atoms into an organism’s metabolites.
App Note / Case Study
4D Lipidomics: Workflow for Increased Throughput
Lipid profiling from complex lipid extracts can be a challenging and time-consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids.
App Note / Case Study
Effortlessly Analyze Pyruvate Kinase Inhibitors
Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.
App Note / Case Study
Distinguishing Oxidative Impurities From Ionizable Lipids Using Electron Activated Dissociation
Lipid nanoparticles (LNPs) comprised of ionizable lipids can be used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system. Detailed and sensitive characterization of the ionizable lipid and its related impurities is necessary to ensure quality, however, obtaining the level of detail needed is challenging with current LC-MS-based methodologies.
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