Latest App Notes & Case Studies

Label-Free Single Cell Proteomics Workflow With the CellenONE Platform and the TimsTOF SCP

Lipid nanoparticles (LNP) play a key role in effectively protecting and transporting mRNA to target cells in mRNA-based vaccines and therapeutics. To ensure the quality and safety of LNP, lipid components and associated impurities/degradants need to be carefully characterized in raw materials and formulation.

Download this app note to discover a solution that boosts the numbers of proteins, peptides and PSMs in complex datasets as well as increases protein sequence coverage substantially.

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities.

Download this application focus to learn more about two novel, sensitive, targeted metabolomics solutions.

However, PTM site localization and quantification of phosphopeptides by collision induced dissociation MS/MS can be challenging, and phospho-peptides can exhibit a partial neutral loss of the phospho group.

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.

COVID-19 is caused by the SARS-CoV-2 virus. While some patients have mild or asymptomatic illness, for others it can be fatal. Understanding the immune response to SARS-CoV-2 at a molecular level is useful for the development of effective vaccines, treatments and prognostic tests.

Liquid Chromatography with tandem mass spectrometry (LC-MS-MS) is a powerful analytical technique that combines the separating power of liquid chromatography with the highly sensitive and selective mass analysis capability of triple quadrupole mass spectrometry.