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Achieve Sensitive Quantitation of GLP Analogs in Biological Matrices

Glycagon
Credit: iStock

Glucagon-like peptide-1 (GLP-1) analogs regulate systemic homeostasis, making them effective in the treatment of type 2 diabetes. However, their low bioavailability limits their detection and quantitation in biological matrices, causing challenges in drug development.

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) can provide a sensitive and selective approach to achieve low levels of quantitation in biological matrices, ensuring the safety and efficacy of peptide analogs during development.

This application note demonstrates the effectiveness of this method for rapidly quantifying a commercially available GLP-1 analog in rat plasma.

Download this application note to discover:

  • How to achieve accurate low levels of quantitation of peptide analogs 
  • Compliance-ready software that supports data acquisition and processing on a single platform 
  • The latest LC-MS/MS method for sensitive, high-confidence detection in biological matrices

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