Latest Articles

Scientists Explore the Molecular Mechanics that Drive us to Sleep
Article

Scientists describe how phosphorylation of 80 synaptic proteins drives our sleep/wake cycles

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Cryo-EM and CX-MS: The Power Couple of Proteomics
Article

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

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Sensitive Quantification of Drug Metabolites Using LC-MS
Article

Determining what happens to a drug after it enters the body is a key consideration in the drug development process. Liquid chromatography coupled with mass spectrometry (LC-MS) has emerged as one of the most powerful analytical tools for the screening and identification of drug metabolites. Advances in the field of LC-MS have allowed scientists to analyze drug metabolic pathways and drug-drug interactions more closely, and improve therapeutic strategies for many challenging diseases.

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The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
Article

Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could result in more successful telomerase-related clinical therapeutics.

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Tech Solutions for Drinking Water Analysis
Article

Improved access to clean and safe drinking water is key for health and survival and has been classified as a human right. Here, we take a look at some of the novel solutions, both hi-tech and low-tech, that scientists are designing to help monitor drinking water source safety.

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Proteomics and Cancer: A Powerful New Revolution
Article

In the post-genomics era, we look at the powerful new revolution in proteomics. We find out how advances are deepening our understanding of cancer biology and resistance processes, which will lead to new clinical applications such as non-invasive biomarkers and drug development.

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Unease on the High Seas: The Effect of Climate Change on Marine Microbial Ecology
Article

Microbes play an important role in the marine ecosystem, however, the effects of climate change have the potential to upset this fine balance, leading to increasing issues with cyanobacterial blooms. Exciting work seeks to look at the knock on effects on the marine food web and ways to combat these toxic blooms.

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Blood Tests for Brain Diseases
Article

Definitive diagnosis for many neurodegenerative diseases – such as Alzheimer’s, Parkinson’s, or Chronic Traumatic Encephalopathy (CTE) – frequently comes far too late. The “true gold standard” for diagnosis of both Alzheimer’s and CTE is through direct postmortem examination of brain tissue. Now, both researchers and athletes are working to change that.

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Exploiting Exosomes for Cancer Diagnosis and Treatment
Article

Evidence is mounting for exosomes playing a central role in many aspects of cancer biology. As researchers start to unravel the secrets of these elusive little vesicles, this is opening a host of exciting new opportunities to tackle cancer – from non-invasive diagnostics to innovative new therapeutics.

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Are Carbon Nanotubes a New Asbestos?
Article

Used in myriad applications and showered with praise by researchers, carbon nanotubes (CNTs) are hailed as a "wonder material" for materials science. This lofty position may be jeopardized by a new study that shows CNTs can induce the fatal cancer mesothelioma in the same way as asbestos.

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