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Protein Purification: Chromatography and Scalability in Biopharma
Article

Prof. Giorgio Carta provides us with extraordinary insight into the current state of play, factors to consider when 'scaling up’ separation processes, and general challenges and developments when applying chromatographic techniques to bioprocesses.

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SWATH-MS Generates Highly Reproducible Data
Article

Scientists looked to address the quantitative and qualitative reproducibility of SWATH-mass spectrometry (MS). The study concluded that detection of large numbers of proteins from highly heterogeneous samples is not only feasible but provides reliable and reproducible quantitative results.

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Mass Spectrometry Improves Osteoporosis Drug Design
Article

We spoke to Professor Patrick Griffin about his advanced mass spectrometry approach to solving challenges in osteoporosis treatment and the wider implications of his work.

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Overcoming Challenges in Biopharma Quantitation with LC-MS
Article

In order to develop an effective LC-MS method to quantify biotherapeutics, technologies should be paired with reliable protein digestion and purification strategies, supported by liquid chromatography instruments that can deliver optimum levels of resolution, sensitivity and throughput.

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Could a Lipid be the Key to Treating Chronic Inflammatory Diseases?
Article

The lipid, 10-nitro-oleic-acid, an endogenous nitro-fatty acid (NFA) modulator, is being explored as a treatment for chronic inflammatory diseases. Prof. Valerie O'Donnell's group was one of the few that originally identified the lipid’s ability to reduce inflammation.

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Metabolomics: Granularizing Diagnostics
Article

Primacy among the ‘omics is debatable, but the notion that metabolomics reflects the most accurate picture of disease states has reached significant momentum.

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Key Challenges and Pain Points in the Global Laboratory Market
Article

To better understand the key challenges and pain points in the global laboratory market, Agilent commissioned Frost & Sullivan to carry out an independent survey of 700 scientists across the laboratory employee spectrum. Here we highlight a selection of the survey’s key findings.

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Industrializing Proteomics to Transform the Future of Healthcare
Article

With very few biomarkers having made it into clinical practice, we find out how some proteomics laboratories are using a factory-type set up to get more biomarkers into the clinic, faster.

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Applied Proteogenomics: A New Weapon in the War Against Cancer
Article

The complexities of tumor genomes are rapidly being uncovered, but how they are regulated into functional proteomes remains poorly understood, until now.

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Mass Spectrometry Workflow Solutions Top Lab Managers’ Wish Lists at ASMS 2017
Article

Streamlining workflows and easing lab manager “pain points” were common themes at this year’s annual meeting of the American Society of Mass Spectrometry (ASMS).

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