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Capillary electrophoresis-mass spectrometry (CE-MS) has remained in the shadows for decades. However, this powerful separation technique is now enjoying a renaissance, with academic and industrial scientists keen to exploit its key advantages. We spoke to some of its most ardent fans to explore a variety of the latest research and clinical applications.

Researchers have worked out the structure of protein progenitor molecules that existed billions of years ago, which may have modern-day uses.

In this article, we provide practical guidance for the application of differential scanning calorimetry (DSC), a core technique for studying the stability and higher order structure (HOS) of proteins. We explain how DSC works, and highlight good practice for ensuring optimal data quality. The interpretation and value of the resulting data is also discussed.

We spoke to Darlene to learn about her reasons for studying science, how she transitioned away from the lab and some of her proudest achievements at Agilent.

It has long been known that the fats we consume in our diet can have an impact on our health. However, their implications on cell differentiation has not previously been understood. We spoke to Professor Ilya Levental about his group's exciting work in this field, the role of lipidomics and how this may affect the future of healthcare.

Mass spectrometry has evolved as a prevailing technique for both the characterization of biotherapeutics and identification of protein variants and post-translational modifications.

Medicine has been moving away from a "one-size-fits-all" approach towards predictive, preventive and treatment strategies tailored to the individual - precision medicine. Quantitative proteomics is playing an important part in this process but there are still some areas in which improvements must be seen before assays are likely to be routinely available to clinicians and patients.

Prof. Giorgio Carta provides us with extraordinary insight into the current state of play, factors to consider when 'scaling up’ separation processes, and general challenges and developments when applying chromatographic techniques to bioprocesses.

The UK’s national synchrotron, Diamond Light Source, celebrates its double anniversary this year. 2017 sees them mark 15 years since the company was formed, and on the 19th October, they commemorated 10 years since their official opening by Her Majesty the Queen.

Scientists looked to address the quantitative and qualitative reproducibility of SWATH-mass spectrometry (MS). The study concluded that detection of large numbers of proteins from highly heterogeneous samples is not only feasible but provides reliable and reproducible quantitative results.