We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Landmark Study Solves Structure of Dementia Protein

Article   Jul 05, 2017 | Adam Tozer PhD, Technology Networks

Structure of Tau Filaments from Alzheimer’s Brain Solved by Cryo-EM

Tau filament structures, rendered in blue and white. In the background, a photomicrograph of a Bodian silver-stain preparation shows a neuron from the cerebral cortex of an individual affected by Alzheimer disease. The cytoplasm around the nucleus contains a flame-shaped neurofibrillary tangle. The Tau filaments appear to wrap around the neuron.

Adam Tozer PhD

Science Writer



The Evolving Field of Cancer Biomarkers


Given the complexity of cancer, it’s arguably unlikely that single molecules will work as clinically meaningful biomarkers for cancer. Today, biomarker discovery involves detecting patterns – characteristics or phenotypes that can be measured and monitored throughout a patient’s journey. Here, we look at two approaches being explored in this evolving field.


Sensitivity vs Specificity


When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results you are obtaining are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow you to evaluate just that.


A Further Dimension to Drug Discovery: Combining 3D Culture With iPSCs


Running in parallel with advances in 3D cell culture is the growing use of human cells derived from induced pluripotent stem cells. Researchers are interested in testing drugs in the most physiologically relevant models possible, so, it was only a matter of time before these two approaches converged – providing optimized systems for disease modeling and drug toxicity testing.



Like what you just read? You can find similar content on the communities below.

Analysis & Separations Drug Discovery Neuroscience

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free