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Accelerating Proteome Analysis With PASEF: A Unique and Sensitive Technique

Accelerating Proteome Analysis With PASEF: A Unique and Sensitive Technique

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Understanding the proteome is a fundamental challenge of biology. Here, Bruker Daltonics' Gary Kruppa and Scarlet Koch outline a new method, Parallel Accumulation Serial Fragmentation (PASEF) that offers faster, more sensitive and more robust proteome analysis, giving scientists the potential to discover low-level, biologically significant proteins and validate them in research.

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How Native MS and Charge Algorithms Can Improve Protein Analysis

How Native MS and Charge Algorithms Can Improve Protein Analysis

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Native Mass Spectrometry (MS) can be used to examine proteins in their natural, folded forms. In this blog, Marshall Bern, Ph.D., the Vice President of Research and Co-Founder of Protein Metrics, discusses how advances in this technique are being paired with cutting-edge charge deconvolution algorithms to improve analysis of antibodies and plasma glycoproteins.

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A New Generation of Flow Cytometers Advances Multiomics

A New Generation of Flow Cytometers Advances Multiomics

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Flow cytometry allows the analysis of physical and biochemical features of cells. Advances in machine that can characterize and sort cells will allow researchers to look deeper than ever before into the proteome and transcriptome. We talk with Bob Balderas, VP Market Development at BD on how the cutting-edge machines like the FACSymphony S6 cell sorter incorporate new technology and advance multiomics research.

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Newly Discovered Biomarker Could Help Diagnose Hearing Loss Earlier

Newly Discovered Biomarker Could Help Diagnose Hearing Loss Earlier

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In collaboration with UConn, Sensorion have identified the first potential biomarker for noise-induced hearing loss, findings which were recently presented at the 53rd American Neurotology Society Annual Spring Meeting.

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Cinderella and Mass Spectrometry: Insightful Multi-Dimensional Data Analysis

Cinderella and Mass Spectrometry: Insightful Multi-Dimensional Data Analysis

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Proteomics is a powerful technology for analyzing low-abundance proteins for disease research. But it’s stalled by imprecise and often irreproducible data analysis. Here, David Chiang, Founder of Sage-N Research, explains how his company uses multidimensional separation to improve peptide identification in MS/MS.

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Data-Independent Acquisition: A Superior Technique in Mass Spectrometry?

Data-Independent Acquisition: A Superior Technique in Mass Spectrometry?

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Whilst Mass Spectrometry is undoubted in its status as a central part of the proteomics toolkit, there is still debate about the way that MS data should be acquired and analyzed. Here, we talk to Florian Marty, Director Global Product Support at Biognosys AG, about why he believes that data-independent acquisition is a superior acquisition technique.

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New Method to Rule out Early Stage Lung Cancer

New Method to Rule out Early Stage Lung Cancer

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We spoke to Dr Albert Luderer, CEO of Integrated Diagnostics to learn about the challenges of diagnosing lung nodules as benign or malignant, and how the Xpresys Lung 2 liquid biopsy test can help improve this process.

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Revolutionizing the World of Pipetting

Revolutionizing the World of Pipetting

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Necessity is the mother of invention, and nowhere is this more clearly demonstrated than in the laboratory. We caught up with Alex Studer, VP of Marketing and Innovation at INTEGRA Biosciences, to discuss the company’s aim to transform the world of pipetting.

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Advances in Analytical Technology: Deciphering Complex Matrices

Advances in Analytical Technology: Deciphering Complex Matrices

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With justice and health in the balance, modern forensic toxicology drug testing labs are expected to detect and quantify a wide range of drugs and metabolites, from Fentanyl to novel psychoactive substances (NPS), at very low levels in biological matrices. The drug concentrations also need to be correlated with the impairment of the individual with absolute certainty, but labs face increasing pressures due to growing caseloads, sample backlogs, and budget restrictions.

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Building in Purity

Building in Purity

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Laboratories rely on the constant provision of high quality water for a variety of purposes, from glass washing to reagent preparation and instrumental analysis. It is all too easy to take this valuable commodity for granted yet, behind the scenes, a great deal of thought goes into designing a facility that reliably and cost-effectively provides water of the required quality on a round the clock basis.

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