Exosomes and Microvesicles in the Circulation
Conference Recording Dec 01, 2013
About the Speaker
Dr. Raymond Schiffelers is Associate Professor of Experimental Laboratory Medicine at the University Medical Center Utrecht (UMCU) within the Laboratory of Clinical Chemistry & Hematology. His research focuses on nanomedicine; nanosized formulations of drugs to improve delivery to sites of diseases and promote cellular uptake. This research is performed in the framework of a European Research Council Starting Grant awarded in 2010, and he also focuses on diagnostics probing nanosized structures in body fluids within a number of small specialized clinical trials performed within and outside the UMCU. His research is applied in nature and has, apart from scientific publications, resulted in a number of patent (applications). The first patented formulation that he (co-)invented, OncoCort® is currently going into a Phase I/II clinical trial. Together with two biotech companies in the Netherlands, 20MED and InteRNA Technologies, he works on improved delivery of siRNA and miRNA. This work will be the topic of this presentation.
Stress on blood: formation of extracellular vesicles. Blood cells respond to stress with release of extracellular vesicles. In particular red blood cells are prone to vesicle release upon a range of stress signals which can range from mechanical stress (e.g. during cardiopumonary bypass procedures) or chemical stress after pharmaceutical intervention (e.g. Taxol). These vesicles carry phosphatidylserine which is thrombogeneic, and carry iron/heme which can cause oxidative stress.