Secretome Proteomics for Tumor Biomarker Discovery
Conference Recording Mar 07, 2013
About the Speaker
Josep Villanueva obtained his PhD in Biochemistry and Molecular Biology from the Universitat Autonoma de Barcelona in the year 2000. In 2009, he returned to Barcelona as an independent researcher and became leader of the VHIO Tumor Biomarkers Group. His research program is aimed at the discovery of new tumor-specific biomarkers and therapeutic targets using proteomic methodologies to improve cancer diagnostics and therapeutic treatment.
Tumor cell communication with its microenvironment plays a key role in tumor initiation and progression. Tumor cells hijack the tumor microenvironment ecosystem via paracrine signaling to promote a pro-oncogenic microenvironment that is critical for the establishment of primary and metastatic tumors. Our working hypothesis is that cellular signaling pathways are altered during tumorigenesis and that these alterations are translated into differential protein secretion, which potentially can also be exploited to discover secreted markers. The methodological focus of our group is based on the quantitative profiling of the cancer secretome. The cancer secretome contains secreted proteins that tumor cells use as molecular SMS to communicate with each other and with their microenvironment, and have a high probability of being present in biological fluids. The presentation will focus on new approaches to identify tumor-specific secreted proteins that can be used to monitor key steps in cancer progression.