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Pathways in Parkinson's Disease
Editor's Pics

Pathways in Parkinson's Disease

Pathways in Parkinson's Disease
Editor's Pics

Pathways in Parkinson's Disease

Parkinson’s disease (PD) affects millions of people worldwide. Mutations or deficiencies in proteins like parkin and PINK1 have been directly linked to autosomal recessive PD. Until recently, the exact pathways involving these proteins was not well-understood. New work by Lee et al. has shown that parkin (aided by PINK1 and its kinase activity) consistently targets PARIS (ZNF746) for ubiquitination and clearance. When parkin and PINK1 are unable to clear PARIS (due to mutations, cell stress, etc.), PARIS accumulates and represses the production of PCG-1α, which is integral to the survival and health of dopaminergic neurons. BioLegend provides highly specific antibodies for the study and detection of these proteins, as well as an informative webpage that explains the mechanisms of PD. Learn more at: www.biolegend.com/parkinsons_disease

Pathways in Parkinson's Disease



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