Target C3 Complement in Astrocytes
Editor's Pics Apr 27, 2017
Astrocytes complete a range of tasks to maintain homeostasis within the CNS. They can also transform following injury or disease via ‘reactive astrocytosis’. Two different types of astrocytes, A1 and A2, can develop following reactive astrocytosis and bear similarity to their M1/M2 macrophage counterparts, as A1 cells may be pro-inflammatory, while A2 cells may promote repair and recovery. C3 complement protein is one of the most highly upregulated genes in A1 astrocytes and cannot be observed in A2 astrocytes. BioLegend offers several antibodies for the detection of C3 complement protein, identifying an A1 phenotype that can help understand neurodegeneration and inflammation in the CNS.