The Role of ApoE4 in the Brain
Editor's Pics Oct 10, 2017
Apolipoproteins, like Apolipoprotein E (ApoE), are proteins that bind lipids to form lipoproteins. While the lipid components of lipoproteins are hydrophobic and insoluble in water, apolipoproteins are amphipathic and are soluble in water. Thus, apolipoproteins facilitate the generation of lipoprotein particles that are water-soluble and can be carried through water-based circulation like blood and lymph. ApoE in the central nervous system (CNS) is produced by astrocytes and microglia, and is a major cholesterol carrier that supports lipid transport and injury repair in the brain.
BioLegend is showcasing a recent study that examines the effect of ApoE4 on tau-mediated neurodegeneration. Learn more at: www.biolegend.com/bio-bits/4719.