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What Customers Say
"At Colossal Biosciences, we only work with non-model organisms and primary cells and cell lines that haven’t been studied before. These cells often fail to grow out after monoclonal isolation using flow sorting. In the few months since adopting the CellRaft, we have isolated thousands of validated monoclonals from elephants, canids and deer with consistent outgrowth efficiencies."
See Colossal's Innovative Research in Reviving Extinct Species like the Woolly Mammoth. See it on CNN.
"We can now easily identify thousands of single organoids with various morphologies (size, shape, complexity) and isolate hundreds in less than an hour. We also use the CellRaft AIR System for cloning of transgenic or CRISPR-edited human intestinal stem cells. Prior to the air system, the efficiency of isolating clonal lines was very inefficient because of the low throughput. Now we can isolate hundreds or thousands of clonal organoids in an unprecedented short amount of time compared to before."
"Several adherent lines tested in the lab do not survive sorting at high pressure and their outgrowth is poor when sorted singly in plates. Manually limiting dilution was previously the only process for obtaining clones; however, we can now utilize the CellRaft AIR® system for adherent lines as well."
"We recommend the CellRaft Technology for our colleagues struggling with single cell isolation. Even with help from FACS, although single cell clones could be obtained, from our experiences, CellRaft not only speeds up this process by providing many more clones but more importantly, the unique monitoring process provided by CellRaft supplies additional information for every single clone with a higher quality of clones ."
“We are the cell engineering group that provides engineered cancer cell lines for cell-based assays to groups across the organization. We have purchased a second CellRaft AIR for our operations as CellRaft AIR has replaced limiting dilution and, to some extent, flow sorting in our workflow. Our workflow demands engineered cells that need to be developed into monoclonal colonies.
A huge advantage for us is the ability to track and trace monoclonality via imaging. I am glad that the response from Cell Microsystems has always been fast in supporting our usage and adoption of the system. The switch to Cellraft Arrays has resulted in a dramatic decrease in reagent usage while increasing our productivity by 2 to 3 fold”
Top 10 Global Biopharma Organization in New York City
“We employed the CellRaft Technology to help isolate clones derived from verified single cells in a cell line that was very difficult to clone by regular limiting dilution. It worked beautifully, producing clones with sequencing-verified distinct genotypes quite easily. This technology is definitely a big advance for anyone trying to isolate clones from single cells!!”
“Our work routinely involves knocking in two or more unrelated fluorescent proteins into a single cell line by lentiviral methods. A significant challenge has been the isolation of strongly expressing all-positive clones for use as reporters. A more facile approach to knocking in and isolating such clones would greatly accelerate our work over engineering alternative construct designs. Cell Microsystems was able to isolate clones of THP-1 monocytes that are highly fluorescent for our assays. I would recommend this technology (CellRaft Technology) as a viable alternative to FACS, especially when cell populations are limiting.”
Unique and Cutting-edge Tools to
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Cell Line, Clone, & Organoid Growth and Isolation System
The CellRaft AIR® System is an integrated platform that uses proprietary technology to maintain cells in an unperturbed state, leading to improved viability of single cells, highly proliferative colonies, and superior clonal outgrowth, which provides a dramatic increase in the number of clones available for downstream applications. With the system, you can:
- Obtain 10 – 50X more viable monoclonal colonies.
- Grow single cells in a flask-like environment, without physically separating them.
- Identify cells of interest using powerful, label-free brightfield or fluorescence analysis software with user-defined parameters.
- Automatically and gently isolate CellRafts containing cells or colonies of interest for downstream endpoint analysis or clonal expansion.
Shear Flow System
The BioFlux Systems offer you the ability to introduce physiological shear flow to your research and drug discovery experiments, effectively emulating in vivo conditions and revealing the true biology.
- Bridge the gap between in vitro and in vivo experiments with controlled shear flow between 0-200 dyn/cm².
- Achieve high throughput with up to 96 flow cell assays run in parallel.
- Expand your capabilities: Dual microenvironments create the ability to easily perform sophisticated assays, such as chemotaxis or invasion.
3D Cell Culture & Bioreactor System
The CERO 3D Incubator & Bioreactor offers a unique 3D cell culture technology to boost your organoid, spheroid, stem cell, and tissue research. This revolutionary instrument creates an optimal cell culture environment by monitoring and controlling temperature, pH and CO2 levels.
- Advanced 3D Culturing: Embrace the full potential of three-dimensional cell growth for tissue engineering, cancer research, and more.
- High-throughput Capability: Efficiently manage multiple experiments simultaneously, saving time and resources.
- Precise Control: Fine-tune your environmental parameters with unparalleled accuracy for consistent results.
Automated Cell Counting & Analysis
The CASY Cell Counter & Analyzer is at the forefront of cellular analysis technology, offering unparalleled precision and efficiency. Designed for the demanding needs of modern laboratories, this state-of-the-art instrument provides accurate, reliable, and rapid cell counting and analysis, enabling scientists to focus on groundbreaking research and results.
- Versatile Sample Compatibility: Able to count large stem cell aggregates to PBMCS to small yeast or bacteria.
- Accurate Cell Counting and Viability Assessment: Utilizes cutting-edge technology to offer precise cell counts and viability assessments, ensuring data integrity for your research.
- Minimal Sample Preparation: Requires no dyes or reagents for cell counting, preserving sample integrity and reducing consumable costs.
Tissue Grinder and Dissociator
The TIGR Tissue Grinder and Dissociator is a novel semi-automated tissue dissociation system. Gentle mechanical dissociation yields high quality single cells in a fast and reproducible manner to facilitate single cell analysis workflows.
- Fast Enzyme-Free Dissociation: Gentle mechanical dissociation is 5-15x faster than enzymatic dissociation.
- Enhanced Integrity and Purity: Integrated workflow in a single consumable reduces risk of contamination.
- Increased Throughput: Benchtop instrument can process 4 individual samples in parallel.
Automated Patch Clamp System
IonFlux Mercury systems offer scalable solutions for automated electrophysiology, providing 16 to 256 parallel channel recordings. Providing one of the lowest costs per data point, well-plate simplicity, user-friendly software, and a space-saving footprint, IonFlux Mercury systems are ready to meet all of your ion channel research and drug discovery needs.
- Fast liquid exchange: Speeds data collection and keeps cells healthy for prolonged experiments
- Continuous solution flow: washes out compounds completely, preventing desensitization.
- Temperature control: enhance physiological relevance with heating up to 40°C and optional cooling.
- High-throughput: 96 or 384-well throughput reduce variability and hands-on time.