Top-down vs. Bottom-up Proteomics

Infographic

Last Updated: August 23, 2019

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Proteomics is an essential tool for the diagnosis, prognosis, and development of disease – since most diseases manifest at the protein activity level. In addition, it also plays a crucial role in drug discovery and development, helping to identify potential therapeutic targets.

The ’bottom-up’ approach has historically been the most commonly used workflow in proteomics, however, more recently the use of ‘top-down’ methods have begun to gain momentum.

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Review both approaches
Learn the main advantages and disadvantages of each approach
Discover the applications each approach is best suited for

Meet the Authors

Laura Elizabeth Lansdowne

Managing Editor

As managing editor, Laura works with the editorial director to create, inform and maintain the overall editorial strategy for Technology Networks. She oversees the in-house editorial team and works directly with commissioned writers to produce content across the publication’s communities. After obtaining a first-class honors degree in biology, Laura worked as a quality assurance technologist before joining the Wellcome Sanger Institute and undertaking an additional qualification in clinical chemistry. In 2015, she left to pursue pharmaceutical and editorial-based roles, before joining Technology Networks in 2017.

Tiffany Quinn

After obtaining a bachelor in neuroscience from the University of Leeds, Tiffany joined Technology Networks to pursue a career in science communication as a custom content producer and manager. She has helped grow the company’s custom content services through creating high-quality and engaging content for client’s target audiences. Tiffany left TN in 2023 to pursue other career goals.