Host Cell Protein Analysis in 2020

Listicle

Last Updated: November 5, 2020

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Published: August 13, 2020

Michele Trott, PhD

Host Cell Protein Analysis in 2020 content piece image

During biotherapeutic production, a range of impurities and variants can be generated, including host cell proteins (HCPs). HCPs present a safety risk as they can produce immunogenic responses and may reduce drug efficacy. To meet regulatory criteria, developers must verify that HCPs have been reduced to an acceptable level.

To keep up with the rapidly growing biotherapeutic industry, the large analytical toolkit of techniques for HCP analysis has continued to evolve.

Download this listicle to discover five recent approaches which help to improve the separation and detection of HCPs, using technologies such as:

One-dimensional liquid chromatography
Advanced biosensors
Host cell line engineering

Meet the Author

Michele Trott, PhD

Michele Trott holds a PhD in endocrinology from Lincoln University. She works as a freelance science writer and scientific content manager for Izon Science.